Me[subscript 3](OMe)tBuXPhos: A Surrogate Ligand for Me[subscript 4]tBuXPhos in Palladium-Catalyzed C-N and C-O Bond-Forming Reactions

摘要

A new biarylphosphine ligand, Me[subscript 3](OMe)tBuXPhos (L3), was designed as a surrogate for Me[subscript 4]tBuXPhos (L1). The Me[subscript 3](OMe)tBuXPhos could be prepared in a chromatography-free manner from inexpensive and readily available 2,3,6-trimethylphenol. Comparative studies demonstrated that a catalyst based on Me[subscript 3](OMe)tBuXPhos displayed the same reactivity as a catalyst based on Me[subscript 4]tBuXPhos for Pd-catalyzed C–N and C–O bond-forming processes.